Holiday Inn St Louis SW - Route 66

Explore St. Louis!

Experience this fully renovated hotel and conference center. Relax at our amazing resort style outdoor heated pool which features luxury cabanas or sit by our fire pit in the evening and relax with a drink. You will hate to leave our resort atmosphere, which is ideal for families, corporate teams or even a staycation with a group of friends. We have a shady seating area overlooking the pool and a place where yard games are set up for a fun family challenge. The absolute best fitness center you will find at any level of hotel will be yet another surprise! Our feature restaurant draws crowds from all over the St. Louis region (www.twistedtreesteakhouse.com). Our lobby bar/restaurant offers a quieter atmosphere and is also operated by Twisted Tree.

Located on historic Route 66 at highway I-44 and I-270, 14 miles from the Gateway Arch! Experience a St. Louis Cardinals game at Busch Stadium, visit the St. Louis Zoo, Missouri Botanical Gardens, Magic House, Six Flags or World Wide Technology Soccer Park.

The hotel is just a short drive to Maritz, Webster University, Harris-Stowe, St. Louis University, and Washington University. Top medical centers, Barnes Jewish Hospital, St. Louis Children's Hospital, SSM, and Mercy Hospitals are nearby.

Welcoming all travelers to our 214-room hotel and 15,500 sq feet of space for your next event. Sunset Event Space is the perfect spot to book your wedding or special event.